NPM attacks are a critical and growing threat that exploit the trust in the open-source software supply chain. These attacks, which often begin with a compromised developer account, can inject malicious code into widely-used packages, with devastating consequences for Web3 applications. Attackers are becoming more sophisticated, using advanced techniques to hijack crypto transactions and steal funds. Mitigating these risks requires a proactive, multi-layered approach, including pinning dependencies, continuous monitoring, and robust security practices from developers. While smart contract audits and bug bounty programs are essential, they must be part of a broader security strategy that also addresses the off-chain components of an application.